HMGBiotech is a biotech company that provides reagents, services and ideas to researchers and companies active in the HMGB field.
The only producer of quality-controlled redox variants of HMGB1
High Mobility Group Box 1 (HMGB1), also known as HMG-1 or amphoterin, is a highly conserved nuclear protein encoded by the HMGB1 gene. As a member of the high mobility group family, HMGB1 contains a characteristic HMG-box domain, which enables its interaction with DNA and other nuclear components.
Featured news
Even after 20 Years, HMGB1 continues to surprise us. A groundbreaking international study has unveile d a critical new role for HMGB1 that could redefine how we think about the biology of aging. Blood protein HMGB1 could be spreading aging throughout the body, acting as a systemic messenger of senescence.
June marks Alzheimer’s & Brain Awareness Month, an important opportunity to advance dialogue on the molecular underpinnings of neurodegeneration.
HMGB1 (High Mobility Group Box 1) isoforms can be used to explore the mechanisms of several disease models.
All proteins are LPS free, so they are suitable for in vitro and in vivo researches.
Fully reduced HMGB1
All the three cysteines are completely reduced. HMGB1 acts as potent chemoattractant for many cells type. Read more…
Disulfide HMGB1
If two cysteines have a disulfide bond. HMGB1 acts as proinflammatory mediator. Read more…
Terminally oxidized HMGB1
The three cysteines are oxidized to sulfonate. HMGB1 is inactive. Read more…
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About us
HMGBiotech has R&D and production unit within Ospedale San Raffaele, one of the leading research institutes in Italy as per volume and quality of scientific output. Read more about our company…
