HMGB2 human

HMGB2 human, LPS-free

HMGB2 is 80% identical to HMGB1 protein, but is encoded by a different gene. It consists of 195 amino acids and has a calculated molecular mass of approximately 22.3 kDa.

The sequence of this product is identical to Homo sapiens.

It contains only trace amounts of LPS (<0.4 ng/mg protein) and it is tested for the ability to induce fibroblast migration.

It has the sequence:

[“MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEE” ]

Purity: The purified protein is >95% homogeneous (electrophoresis). It contains no nucleic acids.
Endotoxin Level: The purified protein is free from LPS (Pierce™ Chromogenic Endotoxin Quant Kit, <0.1 EU/mL). The product contains <0.006% v/v of Triton X-114 due to LPS removal procedure. The remaining traces of Triton X-114 can be removed upon request.
Buffer & Reconstitution: the lyophilized protein once reconstituted with distilled water will be dissolved in a solution containing 50 mM HEPES pH 7.9, 500 mM NaCl and DTT 0,5mM
Storage: the protein is shipped lyophilized. Once resuspended can be stored frozen at -20°C. To avoid cysteine oxidation, DTT 0.5mM is added during protein purification.

This product is intended for research only, and cannot be used on humans.

Publications:

• HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model
• Molecular cloning and functional characterization of HMGB1 and HMGB2 in large yellow croaker Larimichthys crocea
• Single-cell dissection reveals the role of DNA damage response patterns in tumor microenvironment components contributing to colorectal cancer progression and immunotherapy
• Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway
• Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica
• New Insights into the Role of HMGB2 in ST-Segment Elevation Myocardial Infarction
• HMGB2 upregulation promotes the progression of hepatocellular carcinoma cells through the activation of ZEB1/vimentin axis
• Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway
• HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF- κβ Pathway
• Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning
• Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
• Exploring HMGB2 in hepatocellular carcinoma: charting new paths for diagnostic and therapeutic innovations
• Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
• Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions
• Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
• PfHMGB2 has a role in malaria parasite mosquito infection
• Duck HMGB2 Mediates Signaling Pathways in the Innate Immunity of Hosts Against Viral Infections
• IKBKE promotes the ZEB2-mediated EMT process by phosphorylating HMGA1a in glioblastoma
• Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice
• Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF-κB/HMGB-1 pathway
• GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma
• MiR-2113 overexpression attenuates sepsis-induced acute pulmonary dysfunction, inflammation and fibrosis by inhibition of HMGB1
• Therapeutic effects of anti-diabetic drugs on traumatic brain injury
• MicroRNA-146a gene transfer ameliorates senescence and senescence-associated secretory phenotypes in tendinopathic tenocytes
• Toxoplasma gondii Infection Induces High Mobility Group Box 1 Released from Mouse Macrophages
• HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis
• The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion
• High Mobility Group Proteins in Sepsis
• High mobility group A proteins as tumor markers
• The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury
• The Role of High Mobility Group Box 1 in Ischemic Stroke
• [High mobility group nucleosome binding protein 1 (HMGN1) induces activation of mouse BV2 microglia and upregulates their pro-inflammatory mediator expression by activating TLR4/MyD88/NF-κB p65/IKK-β signal pathway]
• Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes
• Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
• Ronfani et al (2001) Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development 128:1265-73

Download HMGB2 Datasheet

Complete Name: High Mobility Group 2
Other Names: Amphoterin-2, High mobility group protein 2,HMG-2, high mobility group protein B2, high-mobility group box 2, Amphoterin, HMG2, HMGB2, SBP-2, recombinant HMGB2