HMGB1, proinflammatory mediator belonging to the alarmin family, is making waves in asthma research.
During tissue inflamation, HMGB1 protein is secreted by various immune cells and has a dual way of entering the extracellular space, either actively secreted or passively released from damaged cells. It interacts with toll-like receptors (TLR) 2 and 4, and RAGE, playing a key role in initiating intracellular signaling pathways.
These interactions help mediate both innate and adaptive immune responses central to asthma. New findings also indicate that HMGB1 collaborates with other receptors like TLR3, TLR9, TIM-3, CD24, and NMDAR.
This contributes to Th2 inflammatory responses, which are critical in asthma pathogenesis.
Understanding HMGB1’s multifaceted role could pave the way for new diagnostic tools and more targeted treatments for asthma.
HMGBiotech can provide all the information to help you make an informed decision for your research purposes involving HMGB1.
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Read the full article about the study: https://pubmed.ncbi.nlm.nih.gov/36924610/
