International Women’s Day, occurring on the 8th of March, is the occasion to emphasize the importance of advancing biomedical research to improve women’s health. Among the critical areas of cancer research, breast cancer remains a leading concern, and HMGB1 protein (High Mobility Group Box 1) is increasingly recognized as a key player in its progression.
HMGB1 as a biomarkers for NACT Response
A study in particular sheds new light on HMGB1 and its role in predicting responses to neoadjuvant chemotherapy (NACT) in breast cancer patients.
NACT, commonly based on docetaxel, epirubicin, and cyclophosphamide (TEC) regimens, aims to reduce tumor size and improve surgical outcomes. However, due to tumor heterogeneity, some patients respond well, while others exhibit resistance. Identifying reliable biomarkers that can accurately reflect treatment response is essential for optimizing therapeutic strategies.
This study found that HMGB1 and E-cadherin levels significantly decrease after NACT, with the reduction in HMGB1 being the most pronounced.
In particular:
- HMGB1 showed the most significant reduction, supporting its role in breast cancer progression and therapy response.
- E-cadherin levels also declined, aligning with previous findings that link its expression to tumor invasiveness.
- The combination of HMGB1 and E-cadherin demonstrated superior predictive power for treatment response compared to either biomarker alone.
These findings suggest that routine monitoring of HMGB1 and E-cadherin levels during NACT could provide an early and accurate assessment of treatment efficacy, helping oncologists adjust therapeutic strategies in real-time for improved outcomes.
On this Women’s Day, has to be remembered the importance in cancer research that empowers women through better diagnostic and personalized treatments. The growing evidence around HMGB1’s role in breast cancer highlights the need for continued exploration, ultimately bringing us closer to precision oncology.
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Read the full article about the study:
https://www.nature.com/articles/s41598-023-41836-5
