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A particularly innovative aspect of the study involved investigating the role of extracellular HMGB1 in dendritic cell-mediated T cell polarization.

Among the most compelling areas of investigation is the intersection between gut microbiota, neuroinflammation, and the multifunctional protein HMGB1 (High Mobility Group Box 1).

HMGB1 actively contributes to immune signaling and plays a significant role in thromboinflammatory disorders such as sickle cell disease (SCD).

World Kidney Day, occurred on March 13th, raises awareness of the important of kidney related researches and therapeutic strategies to fight kidney diseases.

Among the critical areas of cancer research, breast cancer remains a leading concern, and HMGB1 protein is increasingly recognized as a key player in its progression.

On the just occurred World Cancer Day, we had the opportunity to reflect on the growing body of research in cancer development, immune modulation, and drug resistance.

A recent study has revealed that HMGB1 dimerization is a key player in immune signaling. When two HMGB1 molecules join through a Cys106–Cys106 disulfide bond, their #inflammatory potential intensifies.

Two recent studies shed light on how HMGB1 contributes to Kaposi’s sarcoma (KS) and small cell lung cancer (SCLC), revealing new potential therapeutic strategies for cancer.

In 2025 HMGBiotech Srl proudly marks its 20th anniversary, a milestone that reflects two decades of dedication to advancing research on HMGB1 protein.