A recent research has highlighted how HMGB1 (High Mobility Group Box 1) protein in its reduced form plays a crucial role in enhancing cancer cell migration and invasiveness through its interaction with the chemokine CXCL12.
CXCL12/HMGB1 axis to inhibit tumor cell migration and metastasis Read More »
The role of High Mobility Group Box Protein 1 (HMGB1) is increasingly emerging in diabetes-associated complications, particularly diabetic encephalopathy (DE) and diabetic kidney disease (DKD).
Diabetes-related complications: HMGB1 as a potential biomarker and therapeutic target Read More »
High-Mobility Group Box-1 protein (HMGB1) plays a core role in the link between ulcerative colitis (UC) and colorectal cancer (CRC), particularly in colitic carcinoma.
Colitic Carcinoma: effects of HMGB1 protein Read More »
Targeting HMGB1 could represent a novel therapeutic approach for mental health disorders related to stroke and sepsis.
HMGB1 and mental health: bridging neuroinflammation, stroke, and cognitive decline Read More »
World Mental Health Day, occurring on the 10th of October, recalls to us the importance of researches linking inflammation and mental health disorders, in particular major depressive disorder (MDD).
HMGB1 and new frontiers in mental health research Read More »
LPS-free HMGB1 proteins allow for safe and accurate in vitro and in vivo researches, in order to go deeper in heart-related diseases.
Cardiovascular research involving HMGB1 LPS-Free proteins Read More »
A recent research, published two weekes ago, shows that nuclear HMGB1 is essential for the anti-tumor activity of CD8 T cells, particularly in enhancing interferon gamma (IFN-γ) production, a key cytokine in tumor elimination.
Nuclear HMGB1 and anti-tumor immunity Read More »
Emerging research highlights the relevant role of High-Mobility Group Box 1 (HMGB1) in muscular diseases, offering new insights that could inform future therapeutic strategies for SMA.
Spinal Muscular Atrophy and HMGB1 protein Read More »
A recent study has highlighted the significant role of the disulfide form of HMGB1 in liver pathologies related to excessive alcohol consumption.
The role of HMGB1 disulfide form in alcohol-associated liver diseases Read More »
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