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A recent study in the journal Frontiers underscores the association between HMGB1 and autophagy in the progression and complications of diabetes mellitus.

HMGB1, proinflammatory mediator belonging to the alarmin family, is making waves in asthma research.
During tissue inflamation, HMGB1 protein is secreted by various immune cells and has a dual way of entering the extracellular space.

A recent research has highlighted a groundbreaking discovery concerning the connection between HMGB1 released by mesothelial cells and the development of asbestos-induced mesothelioma.

HMGB1 has been shown to play a key role in Parkinson’s disease pathogenesis. Research and studies targeting High Mobility Group Box 1 (HMGB1) protein in Parkinson’s disease (PD) has recently emerged, with promising results in the inhibition of HMGB1.

Recent studies showed HMGB1’s role in the fight against cancer. HMGB1 is increasingly associated with tumor stages, prognosis, immune response and drug resistance.

Latest researches showed that HMGB1 is involved in causing ischemic stroke by ehnancing inflammation and tissue damage in cerebrovascular diseases.

HMGBiotech specializes in the production of LPS-free proteins. LPS (Bacterial endotoxin lipopolysaccharide) is a powerful inducer of the immune system and can introduce undesirable variables and limitations in certain experimental setups.

A recent paper published on Molecular Medicine journal highlights how High Mobility Group Box 1 (HMGB1) and other biomolecules influence fatigue in patients with Crohn’s diseases.

HMGBiotech Srl has taken part to a study, published in June, in which are discovered CXCL12 as the first fuzzy chemokines heterocomplex reported so far and the unexpected role of the acidic intrinsically disordered region (IDR), in HMGB1●CXCL12 heterocomplex formation.