HMGBiotech participated in a recent study in which molecular details of HMGB1●CXCL12 heterocomplex formation were unveiled.
This dynamic complex is formed equimolarly, contrary to previous assumptions: it is highlighted how sructured and unstructured HMGB1 regions interact with the dimerization surface of CXCL12.
This work elucidated how the acidic IDR is involved in HMGB1●CXCL12 complex formation; its findings suggest that interfering with the interactions in the HMGB1●CXCL12 complex could potentially inhibit its detrimental effects in inflammatory conditions.
Read the full article about the study
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