Hmgb2 knock out mouse embryonic fibroblasts [HM-251]
HMGBiotech distributes the knockout cells generated by the laboratory of Prof. Marco E. Bianchi for research purposes. San Raffaele Research Institute remains the owner of the intellectual property associated to these cells, and requires anyone interested in acquiring them to sign an MTA. Please send a mail to info@hmgbiotech.eu for MTA processing.
The cells are shipped in dry ice. Since they are living biological material, they will be checked at customs. Therefore, communication between HMGBiotech and the buyer is required to optimize the delivery.
These Hmgb2 / and Hmgb2-/- MEFs were obtained from sib embryos from crosses of Hmgb2 heterozygotes (Ronfani et al., Development 128: 1265-73) on a pure BALB/c genetic background (>10 backcrosses, unpublished), and grown according to the 3T3 protocol, which prescribes splitting 1:3 the growing cells every 3 days for 3 months.
We suggest to split the cells, by trypsinization, when they reach 80% confluence.
Publications:
- Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway
- HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF- κβ Pathway
- Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning
- Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
- Exploring HMGB2 in hepatocellular carcinoma: charting new paths for diagnostic and therapeutic innovations
- Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
- Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions
- Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
- PfHMGB2 has a role in malaria parasite mosquito infection
- Duck HMGB2 Mediates Signaling Pathways in the Innate Immunity of Hosts Against Viral Infections
- The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
- High-mobility group box-1 peptide ameliorates bronchopulmonary dysplasia by suppressing inflammation and fibrosis in a mouse model
- MIR-107/HMGB1/FGF-2 axis responds to excessive mechanical stretch to promote rapid repair of vascular endothelial cells
- FSHD muscle shows perturbation in fibroadipogenic progenitor cells, mitochondrial function and alternative splicing independently of inflammation
- A Review of Proposed Mechanisms in Rheumatoid Arthritis and Therapeutic Strategies for the Disease
- Blockade of HMGB1 Reduces Inflammation and Pruritus in Atopic Dermatitis by Inhibiting Skin Fibroblasts Activation
- NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
- The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
- Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis
- Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling
