A new research, in which HMGBiotech participated, has unmasked an unexpected player in the world of chemokine interactions: the acidic intrinsically disordered region (IDR).
Traditionally, we have understand chemokines as structured entities, partaking in heterodimeric interactions in order to manage responses to inflammation. This new study shifts such model and focuses on the chemokine CXCL12 and the alarmin HMGB1.
With this research is provided the first evidence that the acidic IDR facilitates the ternary HMGB1•CXCL12•CXCR4 interaction. The acidic IDR in HMGB1 appears instrumental in the heterocomplex formation on the cell surface, distinguishing the interaction of HMGB1 with CXCL12 from the classical rigid heterophilic chemokine-chemokine dimerization.
Read the full article about the study
Discover more and purchase High Mobility Group Box 1 and CXCL12
